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Atherosclerosis (Cardiovascular Disease)

Atherosclerosis is a syndrome affecting arterial blood vessels caused by the accumulation of deposits (plaques) on inner artery walls and the subsequent hardening or furring of the arteries.

Oils, cholesterol, and/or cholic acid (or cholate) are added to standard rodent or rabbit chows in this line of study. Alternatively, one can use purified diets with high fat levels, combined with various levels of cholesterol and/or cholic acid (or cholate). For example, a “Western” diet is a purified diet containing 21% milk fat, 34% sucrose, and 0.2% total cholesterol. Please contact technical service at This e-mail address is being protected from spambots. You need JavaScript enabled to view it for diet details.

-Lichtman AH, Clinton S et al. Hyperlipidemia and Atherosclerosclerotic Lesion Development in LDL Receptor-Deficient Mice Fed Defined Semi purified Diets With and Without Cholate. Arteriosclerosis, Thrombosis and Vascular Biology (1999) 19:1938-1944.
-Cybulsky MI, Iiyama K, Li H, Zhu S, Chen M, Iiyama M, Davis V, Gutierrez-Ramos J-C, Connelly PW, & Milstone DS. A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J. Clin. Invest. (2001) 107:1255-1262.